Effect of some drugs on blood pressure and heart rate of anaesthetized dogs during experimentally induced acidosis and alkalosis.

Male mongrel dogs were used. Methods of inducing acidosis and alkalosis described by Lew et al (5) were followed with modifications. Metabolic acidosis was induced by oral administration of ammonium chloride (5.3 g/day for five days) (n=10). Control animals (n=6) were given sodium chloride (5.85 g/day) in the same manner. Animals were used for the experiments on the sixth day. Metabolic alkalosis was induced under pentobarbitone anaesthesia by iv administration of 200 mlof 0.5 M sodium bicarbonate solution over 10 min followed by infusion at the rate of 5 mIlS min (n=10). Experiments were started immediately afterwards. Controls (n=6) were treated in the same manner using sodium chloride (0.5 M) solution.